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| 1450 |
| | | Francesco Sforza, a soldier of fortune, wins power in Milan | |
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| c. 1450 |
| | | Paolo Uccello is interested in the laws of perspective, in works such as The Battle of San Romano | |
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| 1452 |
| | | Étienne Chevalier commissions from Jean Fouquet a series of illustrations for his Book of Hours | |
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| 1453 |
| | | The Turks terrify Constantinople by lobbing vast stones at the city from a 19-ton bombard of cast iron | |
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| 1453 |
| | | Constantinople falls to a 21-year-old Muslim conqueror, Mehmed II, bringing the Ottoman Turks their capital city | |
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| 1453 |
| | | The Christian emperor Constantine XI dies in the fighting in Constantinople, as the Greek Byzantine empire yields to that of the Ottoman Turks | |
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| 1453 |
| | | The French win a convincing victory at Castillon, recovering the last stronghold (except Calais) held by the English in France | |
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| 1453 |
| | | Charles VII's full recovery of Aquitaine and Normandy effectively brings to an end the Hundred Years' War | |
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| 1455 |
| | | An engagement at St Albans is the first battle in the 30-year struggle between the white and red roses of York and Lancaster | |
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| c. 1455 |
| | | Master ES becomes the first artist to produce engravings | |
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